Adult-onset Still's Disease in a Health Center: A Report of 10 Cases

Jean Noel Diokel Ndour; Bachir Mansour Diallo; Fulgence Faye; Aicha Kaneye; Melissa Derneville; Eunice Thiendrbéogo; Amy Dioum; Atoumane Faye; Adama Berthé; Papa Souleymane Touré; Madoky Magatte Diop; Mamadou Mourtalla Ka

doi:doi:10.11648/j.ajim.20241206.11

Research Article |

| Peer-Reviewed

Adult-onset Still's Disease in a Health Center: A Report of 10 Cases

Jean Noel Diokel Ndour^*

, Bachir Mansour Diallo

, Fulgence Faye, Aicha Kaneye, Melissa Derneville, Eunice Thiendrbéogo, Amy Dioum, Atoumane Faye, Adama Berthé, Papa Souleymane Touré, Madoky Magatte Diop, Mamadou Mourtalla Ka

Published in American Journal of Internal Medicine (Volume 12, Issue 6)

Received: 20 September 2024 Accepted: 11 October 2024 Published: 13 November 2024

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Abstract

Introduction: Adult-onset Still's disease is a rare systemic inflammatory disease in Africa. Observations have been published in Senegal. Materials and Methods: We conducted a retrospective descriptive study to establish the epidemiological profile of patients presenting with adult-onset Still's disease (AOSD) in a health center. The patients included met the diagnostic criteria of Fautrel and/or Yamaguchi. Results: During our study (2020-2024), we included 10 patients with a hospital incidence of 2 patients per year. The average age of the patients was 29.5 years ±11.9, ranging from 15 to 49 years. Females predominated with a sex ratio of 0.67. Clinical manifestations were polymorphic, dominated by fever (100%), inflammatory polyarthralgia (60%), tachycardia (80%), physical asthenia (70%), altered general condition (50%), and erythema (30%). The biological inflammatory syndrome was found in all patients. The glycosylated fraction of ferritin was depleted in all patients. We noted a good outcome after treatment with prednisone 1 mg/kg/day in all patients, methotrexate in six patients, and hydroxychloroquine in one patient. Conclusion: Adult-onset Still's disease is a rare condition, unknown to most practitioners. Its prognosis is severe, especially with visceral involvement.

Published in	American Journal of Internal Medicine (Volume 12, Issue 6)
DOI	10.11648/j.ajim.20241206.11
Page(s)	104-109
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Still’s Disease, Glycosylated Ferritin Fractions, Corticosteroid Therapy

References

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[2]	Fautrel B. Adult-onset Still disease. BPRCR. 2008; 22(5): 773-792.
[3]	Diallo S, Niass M, Adamou L, et al. Maladie de Still: étude de 24 observations au Sénégal. REVRHU. 2022; 89(S1): A129-A130.
[4]	Singwé-Ngandeu M, Biwolé SM, Kagmeni G. La maladie de still de l'adulte vue en rhumatologie a yaounde, cameroun. Sci de la santé. 2010; 11(1): 1-4.
[5]	Ba JI, Nzenze JR, Moubamba F, et al. Maladie de Still en Afrique subsaharienne: à propos de quatre observations gabonaises. Santé. 2011; 21(2): 97-101.
[6]	Frikha O, Derbel A, Mekki S, et al. La maladie de Still de l’adulte: à propos de 65 cas. rev méd interne. 2021; 42(S2): A367-A368.
[7]	Pouchot J. La maladie de Still de l’adulte. Méd thérapeutique. 2007; 13(2): 79-88.
[8]	Arlet JB, Pouchot J. La maladie de Still de l’adulte. Méd thérapeutique. 2007; 13(2): 79-88.
[9]	Gning Sb, Diallo I, Mbaye N M, Fall C A, Ndiaye B, Fall M et Al. Maladie de Still de l’adulte: une observation à Dakar (Sénégal). Med Trop 2011; 71: 588-590.
[10]	Ribi, C., Maladie de Still de l’adulte, Rev Med Suisse, 2008/154(Vol. 4), p. 1039–1044.
[11]	Colafrancesco, R. Priori, G. Valesini. Presentation and diagnosis of adult-onset Still's disease: the implications of current and emerging markers in overcoming the diagnostic challenge, Expert Rev. Clin. Immunol. 11(2015): 749–761.
[12]	Mitrovic S, Fautrel B. New markers for adult-onset Still’s disease. Joint BoneSpine. 2018; 85: 285–293.
[13]	Fautrel B, Le Moel G, Saint Marcoux B Diagnostic value of ferritin and glycosylated ferritin in adult onset Still's disease. J Rheumatol, 2001; 28: 322-329.
[14]	Giacomelli R, Ruscitti P, Shoenfeld Y. A comprehensive review on adult onset still disease. J autoimmun. 2018; 93: 24-36.
[15]	Kir S, Ozgen M, Zontul S. Adult onset still’s disease and treatment results with tocilizumab. Int J Clin Pract. 2021; 75(3): e13936.
[16]	Macovei LA, Burlui A, Bratoiu I, et al. Adult onset still’s disease, a complex disease, a challenging treatment. Int J Mol Sci. 2022; 23(21): 12810.
[17]	Ka MM, Diop MM, Leye A, et al. Auto-immunes diseases problematics in Africa. RAFMI. 2017; 4(1-1): 7-8.
[18]	Ka MM, Diop MM, Touré P S, et al. The challenges of biotherapy in Africa. RAFMI. 2019; 6(1-1): 7-8.
[19]	Ndour MA, Dhiedhiou D, Dieng M, et al. Biotherapy in sub-Saharan Africa: status, challenges, limitations and future prospects: ‘’biotheraf. RAFMI. 2023; 10(1-1): 19-27.

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APA Style

Ndour, J. N. D., Diallo, B. M., Faye, F., Kaneye, A., Derneville, M., et al. (2024). Adult-onset Still's Disease in a Health Center: A Report of 10 Cases. American Journal of Internal Medicine, 12(6), 104-109. https://doi.org/10.11648/j.ajim.20241206.11

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ACS Style

Ndour, J. N. D.; Diallo, B. M.; Faye, F.; Kaneye, A.; Derneville, M., et al. Adult-onset Still's Disease in a Health Center: A Report of 10 Cases. Am. J. Intern. Med. 2024, 12(6), 104-109. doi: 10.11648/j.ajim.20241206.11

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AMA Style

Ndour JND, Diallo BM, Faye F, Kaneye A, Derneville M, et al. Adult-onset Still's Disease in a Health Center: A Report of 10 Cases. Am J Intern Med. 2024;12(6):104-109. doi: 10.11648/j.ajim.20241206.11

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@article{10.11648/j.ajim.20241206.11,
  author = {Jean Noel Diokel Ndour and Bachir Mansour Diallo and Fulgence Faye and Aicha Kaneye and Melissa Derneville and Eunice Thiendrbéogo and Amy Dioum and Atoumane Faye and Adama Berthé and Papa Souleymane Touré and Madoky Magatte Diop and Mamadou Mourtalla Ka},
  title = {Adult-onset Still's Disease in a Health Center: A Report of 10 Cases
},
  journal = {American Journal of Internal Medicine},
  volume = {12},
  number = {6},
  pages = {104-109},
  doi = {10.11648/j.ajim.20241206.11},
  url = {https://doi.org/10.11648/j.ajim.20241206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20241206.11},
  abstract = {Introduction: Adult-onset Still's disease is a rare systemic inflammatory disease in Africa. Observations have been published in Senegal. Materials and Methods: We conducted a retrospective descriptive study to establish the epidemiological profile of patients presenting with adult-onset Still's disease (AOSD) in a health center. The patients included met the diagnostic criteria of Fautrel and/or Yamaguchi. Results: During our study (2020-2024), we included 10 patients with a hospital incidence of 2 patients per year. The average age of the patients was 29.5 years ±11.9, ranging from 15 to 49 years. Females predominated with a sex ratio of 0.67. Clinical manifestations were polymorphic, dominated by fever (100%), inflammatory polyarthralgia (60%), tachycardia (80%), physical asthenia (70%), altered general condition (50%), and erythema (30%). The biological inflammatory syndrome was found in all patients. The glycosylated fraction of ferritin was depleted in all patients. We noted a good outcome after treatment with prednisone 1 mg/kg/day in all patients, methotrexate in six patients, and hydroxychloroquine in one patient. Conclusion: Adult-onset Still's disease is a rare condition, unknown to most practitioners. Its prognosis is severe, especially with visceral involvement.
},
 year = {2024}
}

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TY  - JOUR
T1  - Adult-onset Still's Disease in a Health Center: A Report of 10 Cases

AU  - Jean Noel Diokel Ndour
AU  - Bachir Mansour Diallo
AU  - Fulgence Faye
AU  - Aicha Kaneye
AU  - Melissa Derneville
AU  - Eunice Thiendrbéogo
AU  - Amy Dioum
AU  - Atoumane Faye
AU  - Adama Berthé
AU  - Papa Souleymane Touré
AU  - Madoky Magatte Diop
AU  - Mamadou Mourtalla Ka
Y1  - 2024/11/13
PY  - 2024
N1  - https://doi.org/10.11648/j.ajim.20241206.11
DO  - 10.11648/j.ajim.20241206.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 104
EP  - 109
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20241206.11
AB  - Introduction: Adult-onset Still's disease is a rare systemic inflammatory disease in Africa. Observations have been published in Senegal. Materials and Methods: We conducted a retrospective descriptive study to establish the epidemiological profile of patients presenting with adult-onset Still's disease (AOSD) in a health center. The patients included met the diagnostic criteria of Fautrel and/or Yamaguchi. Results: During our study (2020-2024), we included 10 patients with a hospital incidence of 2 patients per year. The average age of the patients was 29.5 years ±11.9, ranging from 15 to 49 years. Females predominated with a sex ratio of 0.67. Clinical manifestations were polymorphic, dominated by fever (100%), inflammatory polyarthralgia (60%), tachycardia (80%), physical asthenia (70%), altered general condition (50%), and erythema (30%). The biological inflammatory syndrome was found in all patients. The glycosylated fraction of ferritin was depleted in all patients. We noted a good outcome after treatment with prednisone 1 mg/kg/day in all patients, methotrexate in six patients, and hydroxychloroquine in one patient. Conclusion: Adult-onset Still's disease is a rare condition, unknown to most practitioners. Its prognosis is severe, especially with visceral involvement.

VL  - 12
IS  - 6
ER  -

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Author Information

Jean Noel Diokel Ndour

Department of Internal Medicine, Mamadou Diop Health Center, Dakar, Senegal

Contact Email

http://orcid.org/0009-0004-6462-2623
Bachir Mansour Diallo

Department of Internal Medicine, Abdou Aziz Sy Dabakh Hospital, Tivaouane, Senegal

http://orcid.org/0000-0001-7574-4168
Fulgence Faye

School of Medecine, Alioune Diop University, Bambey, Senegal
Aicha Kaneye

Department of Internal Medicine, Mamadou Diop Health Center, Dakar, Senegal; School of Medecine, Saint Christopher University, Dakar, Senegal
Melissa Derneville

Department of Internal Medicine, Mamadou Diop Health Center, Dakar, Senegal; School of Medecine, Saint Christopher University, Dakar, Senegal
Eunice Thiendrbéogo

Department of Internal Medicine, Mamadou Diop Health Center, Dakar, Senegal; School of Medecine, Iba Der Thiam University, Thiès, Senegal
Amy Dioum

Department of Internal Medicine, Mamadou Diop Health Center, Dakar, Senegal; School of Medecine, Iba Der Thiam University, Thiès, Senegal
Atoumane Faye

Department of Internal Medicine, Mamadou Diop Health Center, Dakar, Senegal; School of Medecine, Cheikh Anta Diop University, Dakar, Senegal
Adama Berthé

Department of Internal Medicine, Regional Hospital of Thiès, Thies, Senegal
Papa Souleymane Touré

Department of Internal Medicine, Abdou Aziz Sy Dabakh Hospital, Tivaouane, Senegal
Madoky Magatte Diop

Department of Internal Medicine, Regional Hospital of Thiès, Thies, Senegal
Mamadou Mourtalla Ka

School of Medecine, Iba Der Thiam University, Thiès, Senegal

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Plain Text BibTeX RIS

APA Style

Ndour, J. N. D., Diallo, B. M., Faye, F., Kaneye, A., Derneville, M., et al. (2024). Adult-onset Still's Disease in a Health Center: A Report of 10 Cases. American Journal of Internal Medicine, 12(6), 104-109. https://doi.org/10.11648/j.ajim.20241206.11

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ACS Style

Ndour, J. N. D.; Diallo, B. M.; Faye, F.; Kaneye, A.; Derneville, M., et al. Adult-onset Still's Disease in a Health Center: A Report of 10 Cases. Am. J. Intern. Med. 2024, 12(6), 104-109. doi: 10.11648/j.ajim.20241206.11

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AMA Style

Ndour JND, Diallo BM, Faye F, Kaneye A, Derneville M, et al. Adult-onset Still's Disease in a Health Center: A Report of 10 Cases. Am J Intern Med. 2024;12(6):104-109. doi: 10.11648/j.ajim.20241206.11

Copy | Download

@article{10.11648/j.ajim.20241206.11,
  author = {Jean Noel Diokel Ndour and Bachir Mansour Diallo and Fulgence Faye and Aicha Kaneye and Melissa Derneville and Eunice Thiendrbéogo and Amy Dioum and Atoumane Faye and Adama Berthé and Papa Souleymane Touré and Madoky Magatte Diop and Mamadou Mourtalla Ka},
  title = {Adult-onset Still's Disease in a Health Center: A Report of 10 Cases
},
  journal = {American Journal of Internal Medicine},
  volume = {12},
  number = {6},
  pages = {104-109},
  doi = {10.11648/j.ajim.20241206.11},
  url = {https://doi.org/10.11648/j.ajim.20241206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20241206.11},
  abstract = {Introduction: Adult-onset Still's disease is a rare systemic inflammatory disease in Africa. Observations have been published in Senegal. Materials and Methods: We conducted a retrospective descriptive study to establish the epidemiological profile of patients presenting with adult-onset Still's disease (AOSD) in a health center. The patients included met the diagnostic criteria of Fautrel and/or Yamaguchi. Results: During our study (2020-2024), we included 10 patients with a hospital incidence of 2 patients per year. The average age of the patients was 29.5 years ±11.9, ranging from 15 to 49 years. Females predominated with a sex ratio of 0.67. Clinical manifestations were polymorphic, dominated by fever (100%), inflammatory polyarthralgia (60%), tachycardia (80%), physical asthenia (70%), altered general condition (50%), and erythema (30%). The biological inflammatory syndrome was found in all patients. The glycosylated fraction of ferritin was depleted in all patients. We noted a good outcome after treatment with prednisone 1 mg/kg/day in all patients, methotrexate in six patients, and hydroxychloroquine in one patient. Conclusion: Adult-onset Still's disease is a rare condition, unknown to most practitioners. Its prognosis is severe, especially with visceral involvement.
},
 year = {2024}
}

Copy | Download

TY  - JOUR
T1  - Adult-onset Still's Disease in a Health Center: A Report of 10 Cases

AU  - Jean Noel Diokel Ndour
AU  - Bachir Mansour Diallo
AU  - Fulgence Faye
AU  - Aicha Kaneye
AU  - Melissa Derneville
AU  - Eunice Thiendrbéogo
AU  - Amy Dioum
AU  - Atoumane Faye
AU  - Adama Berthé
AU  - Papa Souleymane Touré
AU  - Madoky Magatte Diop
AU  - Mamadou Mourtalla Ka
Y1  - 2024/11/13
PY  - 2024
N1  - https://doi.org/10.11648/j.ajim.20241206.11
DO  - 10.11648/j.ajim.20241206.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 104
EP  - 109
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20241206.11
AB  - Introduction: Adult-onset Still's disease is a rare systemic inflammatory disease in Africa. Observations have been published in Senegal. Materials and Methods: We conducted a retrospective descriptive study to establish the epidemiological profile of patients presenting with adult-onset Still's disease (AOSD) in a health center. The patients included met the diagnostic criteria of Fautrel and/or Yamaguchi. Results: During our study (2020-2024), we included 10 patients with a hospital incidence of 2 patients per year. The average age of the patients was 29.5 years ±11.9, ranging from 15 to 49 years. Females predominated with a sex ratio of 0.67. Clinical manifestations were polymorphic, dominated by fever (100%), inflammatory polyarthralgia (60%), tachycardia (80%), physical asthenia (70%), altered general condition (50%), and erythema (30%). The biological inflammatory syndrome was found in all patients. The glycosylated fraction of ferritin was depleted in all patients. We noted a good outcome after treatment with prednisone 1 mg/kg/day in all patients, methotrexate in six patients, and hydroxychloroquine in one patient. Conclusion: Adult-onset Still's disease is a rare condition, unknown to most practitioners. Its prognosis is severe, especially with visceral involvement.

VL  - 12
IS  - 6
ER  -

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