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Evar Acute Results in Patients with Hostile Proximal Aneurysmal Neck
Sergey Furkalo,
Inna Khasyanova,
Andriy Khokhlov
Issue:
Volume 10, Issue 3, May 2022
Pages:
34-38
Received:
12 February 2022
Accepted:
25 April 2022
Published:
10 May 2022
Abstract: About 40% of patients with AAA, due to the anatomical characteristics of the aorta, cannot be candidates for EVAR. Anatomical features that are difficult or unacceptable for stent-graft placement include short or no proximal neck, angular, tapered neck, and vessel diameter that exceeds the existing capabilities of endoprostheses. In patients where traditional surgical correction is not an acceptable option, various technological methods and equipment are used. The observation included 18 consecutive patients with AAA, where EVAR was performed. When analyzing the anatomical characteristics of the aneurysmal sac, 9 (50%) patients were classified as patients with an unfavorable proximal neck of the aneurysm, the so-called “hostile neck”. 4 EVAR interventions were complex (2 patients with parallel grafts), which made it possible to achieve an increase in the proximal infrarenal zone implantation up to 16-20 mm, and supplemented or additional endovascular procedures - in our case, implantation of “Aptus Heli-FX” endoancors in 5 patients. The comparison group consisted of 9 patients with a standard aneurysm neck, where standard EVAR procedures were performed. The main anatomical difference in the groups was the length of the aneurysm neck - 9.8 mm and 36.1 mm in groups I and II, respectively (p - 0,0003). EVAR in the groups were carried out without significant complications and operation death; in the first group, the duration of the operation (p-0,01), the amount of contrast (p-0,03) and the fluoro time (p - 0,01) were significantly increased than in the patients of group II. The postoperative period did not differ between the groups. So the use of modern technological methods allows to significantly expand the indications for EVAR in patients with unfavorable anatomy.
Abstract: About 40% of patients with AAA, due to the anatomical characteristics of the aorta, cannot be candidates for EVAR. Anatomical features that are difficult or unacceptable for stent-graft placement include short or no proximal neck, angular, tapered neck, and vessel diameter that exceeds the existing capabilities of endoprostheses. In patients where ...
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Curative Drug Treatments for Post-Traumatic Stress Disorder: A Systematic Review of the Effectiveness of Recent Treatments
Cyril Coquemont,
Cyril Georges,
Bernard Massoubre,
Catherine Massoubre,
Caroline Boulliat
Issue:
Volume 10, Issue 3, May 2022
Pages:
39-50
Received:
17 March 2022
Accepted:
13 April 2022
Published:
10 May 2022
Abstract: Post-traumatic stress disorder (PTSD) is a severe anxiety disorder with clinical and social repercussions. The first line of treatment is psychotherapy, but the most advanced forms require, in addition, a drug treatment. Currently, the treatments used are few in number and not very effective. The objective is to review the recent literature on curative drug treatments for PTSD. We conducted a literature review on the Medline database to include articles less than 10 years old dealing with curative drug treatments for PTSD. We identified inclusion and exclusion criteria to frame our research. We first selected articles by reading the title, then the abstract, and finally the full text. Each clinical study was placed in a table with its main characteristics and then analyzed in order to determine the effectiveness of the treatment studied. 51 references were included. Beta-blockers, corticosteroids and D-cycloserine show positive results in combination with various psychotherapy methods. Antiepileptics, oxytocin, atypical antipsychotics and prazosin showed divergent results. The use of prazosin, currently used to treat PTSD-induced sleep disorders, is being questioned. Ketamine, MDMA and cannabinoids have shown satisfactory results in terms of efficacy, but the question of their safety of use remains. The risks of overdose and illegal use should not be overlooked. Molecules such as ketamine, MDMA or cannabinoids will require further studies to conclude their efficacy and safety. They appear to be the most promising molecules currently available for the treatment of PTSD.
Abstract: Post-traumatic stress disorder (PTSD) is a severe anxiety disorder with clinical and social repercussions. The first line of treatment is psychotherapy, but the most advanced forms require, in addition, a drug treatment. Currently, the treatments used are few in number and not very effective. The objective is to review the recent literature on cura...
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Selenium, Zinc and Copper: Can Their Deficiency Facilitate Complications COVID-19 and Omicron Pandemic
Pasquale Ruffolo,
Marco Trifuoggi,
Ferdinando Mazzei,
Francesco Mazzei,
Bruno Ruffolo,
Manuela Panunzio,
Ilaria Zampella,
Antonio Marfella
Issue:
Volume 10, Issue 3, May 2022
Pages:
51-55
Received:
25 March 2022
Accepted:
22 April 2022
Published:
12 May 2022
Abstract: Two years after the beginning of the COVID-19 pandemic, we set out to evaluate with this study the possible correlations between the complications from COVID-19 disease and omicron disease with selenium, zinc and copper deficiency or with the presence of some heavy metals or dioxins. The main objective of this study is that deficient in selenium, zinc and copper cannot avoid the risk of contagion, but can reduce the occurrence of complications. Therefore it seems appropriate to advise to control and rebalance the values of selenium, zinc and copper to deal in the best possible way with various bacterial and viral diseases and in particular a new possible viral pandemic. The above findings make us ponder over the impossibility of escaping the risk of contagion but, nevertheless, we can reduce its complications. So the question to ask is not if “we can escape the disease but how we can prevent its complications.” The challenge for us is to succeed in predicting the onset of different complications. Checking the right range of selenium, zinc and copper is important not to avoid contagion but to reduce symptoms and complication, not only in pandemics, but also in the treatment of many infectious diseases and cancers, in the last it is useful to check the excessive presence of different toxic metals that may affect the result of the therapy practiced and put patients’ health at risk. It means that it is better not to wait clinical signs to undergo diagnostic and instrumental tests that will, probably, show only a state of ongoing illness. Often such clinical investigations are performed in an incomplete, superficial and improper way. We even know that it is not easy to identify toxic substances because of difficulties related to their determination, and, first of all, for the small number of medical doctors competent to advise and to interpret medical tests according to reference values. Nowadays a very good early diagnosis is performed by using accurate and technologically advanced instrumental methods but, if instrumental diagnostic could be used alongside tests for heavy metals, dioxins, IPA, present into different biological matrix it would be possible to start a program of early clinical biochemistry diagnosis in order to prevent the complications related to these infectious diseases.
Abstract: Two years after the beginning of the COVID-19 pandemic, we set out to evaluate with this study the possible correlations between the complications from COVID-19 disease and omicron disease with selenium, zinc and copper deficiency or with the presence of some heavy metals or dioxins. The main objective of this study is that deficient in selenium, z...
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Clinical Presentation and Biological Modification of Hospitalized Patients for COVID-19 in the Democratic Republic of Congo
Blaise Makoso Nimi,
Benjamin Longo Mbenza,
Timothee Mawisa Nkemfuni,
Steve Tulantched Mingana,
Gaston Katomba Zeba,
Piroger Phoba Mbadu,
Firmin Mbambi Nsungu,
Fabrice Nlandu Makungu,
Christian Kisoka Lusunsi
Issue:
Volume 10, Issue 3, May 2022
Pages:
56-61
Received:
9 March 2022
Accepted:
25 March 2022
Published:
24 May 2022
Abstract: Background and aims: the whole of humanity has experienced since December 2019 a pandemic of coronavirus disease 2019 (COVID-19), caused by the coronavirus. Unprecedented situation in this century especially for the DR Congo with a less equipped health system. The objective of this study is to describe the clinico-biological profile of patients hospitalized at the Cinquantenaire Hospital of Kinshasa in DR Congo. Methods: This was a retrospective, analytical and descriptive cohort study carried out among 360 patients hospitalized at the Cinquantenaire Hospital in Kinshasa from the period from April 18, 2020 to July 10, 2021. Results: The average age was 42.7 ± 12.0 years with a female predominance, 57.7% of patients were over 50 years old. Comorbidities such as hypertension, diabetes mellitus and bronchial asthma were present respectively in 25.2% and 4.2% and 12.3%. The symptomatology was dominated by cough, fever and asthenia in more than The most common biological abnormalities were as follows: increased CRP (57.7%), basocytaemia (55%), hepatic cytolysis (20.6%), elevated D-dimer (15.3%), decreased TP (17.5%) lymphopenia (16.7%), anemia (11.1%) and Hyperleukocytosis 10.6% Conclusion: COVID-19 infection should be considered as sepsis with multi-visceral involvement although the lung is first. Both biological and hematological abnormalities may be encountered.
Abstract: Background and aims: the whole of humanity has experienced since December 2019 a pandemic of coronavirus disease 2019 (COVID-19), caused by the coronavirus. Unprecedented situation in this century especially for the DR Congo with a less equipped health system. The objective of this study is to describe the clinico-biological profile of patients hos...
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New Horizon on Gut Microbiome and Cancers: Recent Information on Pathogenesis and Treatment
Issue:
Volume 10, Issue 3, May 2022
Pages:
62-70
Received:
4 May 2022
Accepted:
26 May 2022
Published:
9 June 2022
Abstract: An increasing number of studies have suggested that gut microbiota is closely related to tumor pathogenesis and their treatments. Among cancers, there have been many reports concerning gut microbiome and colon cancer (CRC), where microbial dysbiosis with depressing the population of “benign microbes” and increasing “harmful microbes” can lead to chronic enterocolitis and cancer development with progression. In addition, gut dysbiosis may change the metabolism of bile acids promoting CRC, which would offer a potential preventive therapeutic change in CRC by regulating gut microbiome and bile acid metabolism. Recently, SARS-CoV-2 impacts the gut microbiota, and the effects will have on CRC carcinogenesis. Obesity is estimated as an important factor that increases the risk of CRC. There has been accumulating evidence that the modulation of the gut microbiota composition by probiotics, prebiotics, and diets protects patients with CRC. Hepatocellular carcinoma (HCC) as the third leading cause of worldwide cancer mortality. Development of HCC in cirrhotic patients is related to changes in intestinal microbiome, including an escalation of dysbiosis and reduced bacterial richness. The species richness of fecal microbiota of hepatitis B-HCC patients was much high. The alterations of fecal microbiome may affect the process of Helicobacter pylori (H. pylori)-related progression of gastric lesion. Patients with gastric cancer have distinct microbiome in the stomach with lower biodiversity. Some bacteria from gastric microbiome are potentially carcinogenic as they are changed in gastric cancer. Patients with pancreas cancer and cholangiocarcinoma have also been related to gut dysbiosis. Other malignancies outside the gut like breast cancer (BC) might be related to gut microbiome as they might affect through metabolic, neural, and endocrine signal and immune function in the occurrence and progression of BC. Finally, cancer cachexia might be also associated with gut dysbiosis as it is closely related to bile acids (BA) metabolism regulation. The effects and side effects by variable cancer therapies such as chemotherapy, radiotherapy and also immunotherapy may be reconsidered from gut microbiome.
Abstract: An increasing number of studies have suggested that gut microbiota is closely related to tumor pathogenesis and their treatments. Among cancers, there have been many reports concerning gut microbiome and colon cancer (CRC), where microbial dysbiosis with depressing the population of “benign microbes” and increasing “harmful microbes” can lead to ch...
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Seroprevalence of Hepatitis B Virus in N'Djamena, Chad
Mayanna Habkreo,
Hassan Adam Annour,
Gouaye Yahvourne Daiba,
Maire Dehainssala,
Adama Ngare,
Moussa Elefi,
Tahir Mahamat Saleh,
Ali Mahamat Moussa,
Ibrahim Hamat
Issue:
Volume 10, Issue 3, May 2022
Pages:
71-74
Received:
30 May 2022
Accepted:
24 June 2022
Published:
30 June 2022
Abstract: Introduction: Chronic hepatitis B virus infection is very common in sub-Saharan Africa and widely distributed worldwide. The purpose of this study was to determine the prevalence of hepatitis B virus in N'Djamena, Chad. Methodology: This was a cross-sectional study conducted in the city of N'Djamena. Three neighborhoods were randomly selected. The methodology applied was a two-stage probability survey with the neighborhoods as the primary unit and the squares (sectors) as the secondary unit. Persons from the selected households were screened for HBV infection. Results: Two hundred and ninety-nine (299) individuals were recruited in this study series. The majority were men (69.6%). The mean age was 29.5 ± 9 years with extremes of 15 to 45 years. The prevalence of those screened was 24.1% with a male predominance (54.1%). There was a statistically significant difference between HBsAg carriage and sex (p = 0.001). On the other hand, the difference between HBV carriage and education level was not statistically significant. In addition, few people had information on the modes of transmission of HBV and their serological status. Conclusion: Viral hepatitis B is a major global public health problem. However, most of the people recruited in this series were unaware of their status and very few had information on this disease.
Abstract: Introduction: Chronic hepatitis B virus infection is very common in sub-Saharan Africa and widely distributed worldwide. The purpose of this study was to determine the prevalence of hepatitis B virus in N'Djamena, Chad. Methodology: This was a cross-sectional study conducted in the city of N'Djamena. Three neighborhoods were randomly selected. The ...
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Evaluation of the Knowledge and Attitudes of Students at the University of N'Djamena on Hepatitis B
Mayanna Habkreo,
Maire Dehainssala,
Tahir Mahamat Saleh,
Gouaye Yahvourne Daiba,
Adama Ngare,
Awadjakwa Bonsala,
Ali Mahamat Moussa,
Ibrahim Hamat
Issue:
Volume 10, Issue 3, May 2022
Pages:
75-78
Received:
30 May 2022
Accepted:
24 June 2022
Published:
30 June 2022
Abstract: Introduction: Viral hepatitis B constitutes a real global public health problem. According to the WHO, Chad is one of the so-called high endemic areas for the hepatitis B virus. The aim of this study was to improve the prevention of hepatitis B virus in the university environment. Methodology: This was a cross-sectional study with a descriptive aim, spread over a period of one year. The university campus of Toukra and the Faculty of Exact and Applied Sciences of Farcha were used as study settings. The data were collected on a standardized form. Results: Five hundred (500) students were interviewed. The average age was 23.06 ± 2.8 years. The sex ratio was 2.9. The vast majority (91.4%) had heard of viral hepatitis B. School and university awareness were the main sources of information. The clinical signs frequently cited by the respondents were fatigue and fever. However, little was known about the mode of transmission. The majority cited saliva as the source of contamination (76.2%). Among the means of prevention, vaccination was cited by 55.8% of participants. Only 19.4% of the participants admitted to being immune to the virus. However, 79.8% wanted to be vaccinated against the disease. The majority (83.4%) felt that going to the health service was the best way to deal with HBV exposure. Conclusion: Although most respondents had good knowledge of the disease, very few were vaccinated. There is a need to expand vaccination to the general population.
Abstract: Introduction: Viral hepatitis B constitutes a real global public health problem. According to the WHO, Chad is one of the so-called high endemic areas for the hepatitis B virus. The aim of this study was to improve the prevention of hepatitis B virus in the university environment. Methodology: This was a cross-sectional study with a descriptive aim...
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